A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Nanotechnology offers a range of options to lead to biology. Listed here I'll current illustrations where by nanofabrication – the ability to make confined structures with dimensions at will – is used to examine the biophysics of single molecules and cells. I will present some illustrations from our lab:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I
Given that 2000, Dekker has shifted the most crucial target of his get the job done towards biophysics in which he experiments the properties of single biomolecules and cells using the instruments of nanotechnology. This transformation of discipline was pushed by his fascination with the outstanding operating of Organic molecular buildings, and from the extended-expression standpoint that numerous fascinating discoveries could be predicted With this industry.[five] Present-day lines of research in his biophysics group are inside the regions of:[6]
2015, discovery that condensin is actually a extremely adaptable protein framework; and initial detection of DNA knots using nanopores
SMC complexes can move Bodily roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
‘In the beginning we checked out Organic methods by using a Actual physical view and acted on the basis on the applications we knew. It took a couple of years ahead of we begun Operating a lot more on the large Organic challenges. I then started to contact it nanobiology, a phrase that didn't exist at enough time.
Nanopores signify an elegant and versatile tool to evaluate one molecules. We investigate novel detection modes with good-point out nanopores and many tips on how to evaluate proteins with nanopores. Assignments ceesdekker encompass the next:
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one). The existing–voltage curves showed sizeable modulations with gate voltage, even at space temperature, which was according to band bending within a ~0.six eV bandgap semiconducting nanotube. These information also confirmed which the conductance could possibly be modulated by 6 orders of magnitude by altering the gate voltage. The effects of this operate — a room-temperature transistor created from only one carbon nanotube molecule — had been released in Mother nature in Could 1998.
In 1993 he was appointed as Associate Professor at Delft University of Know-how. In the mid-1990s Dekker and his crew obtained achievement with the invention of your Digital Qualities of carbon nanotubes, the primary one-molecule transistor and other nanoscience.
Quite a few new phenomena had been found out, and he and his investigation group proven a leading situation Within this subject of analysis. Dekker and his investigate group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the primary to build a transistor determined by a single nanotube molecule.
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It was an incredibly attention-grabbing time, throughout which I acquired loads of assistance from Delft University of Technological innovation, where by I was a professor at time, and I commenced various collaborations with molecular biologists. That served me discover a whole lot.’